2-Hydroxy-3-methylbutyric acid methyl ester

Base Information

• Chemical Name: 2-Hydroxy-3-methylbutyric acid methyl ester
• CAS No.: 17417-00-4
• Molecular Formula: C6H12O3
• Molecular Weight: 132.159
• Hs Code.: 2918199090
• Mol file: 17417-00-4.mol

Synonyms:Butyric acid,2-hydroxy-3-methyl-,methyl ester;Methyl-2-hydroxy-3-methyl butanoate;methyl 2-hydroxy-isovalerate;2-hydroxy-3-methyl-butyric acid methyl ester;Butanoic acid,2-hydroxy-3-methyl-,methyl ester;

Chemical Property of 2-Hydroxy-3-methylbutyric acid methyl ester

Chemical Property:

• Boiling Point: 62-63 °C(Press: 15 Torr)
• PKA: 12.94±0.20(Predicted)
• PSA: 46.53000
• Density: 1.021±0.06 g/cm3(Predicted)
• LogP: 0.17630

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-hydroxy-3-methylbutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxy-3-methylbutyric acid methyl ester

There total 10 articles about 2-Hydroxy-3-methylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-hydroxy-3-methylbutanoic acid (4026-18-0,17407-55-5,17407-56-6,600-37-3) → methyl 2-hydroxy-3-methylbutanoate (17417-00-4)

Guidance literature:

In diethyl ether; at 24 ℃;

DOI:10.1021/jo00068a047

Reference yield: 92.0%

methyl 3-methyl-2-ketobutanoate (3952-67-8) → methyl 2-hydroxy-3-methylbutanoate (17417-00-4)

Guidance literature:

With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium hydrogencarbonate; In methanol; at 25 ℃; for 12h; under 7500.75 Torr; chemoselective reaction; Glovebox; Autoclave;

DOI:10.1055/s-0035-1561971

Reference yield: 91.9%

→ methyl 2-hydroxy-3-methylbutanoate (17417-00-4)

Guidance literature:

With hydrogenchloride; at 80 - 90 ℃;

upstream raw materials:

diazomethane

2-hydroxy-3-methylbutanoic acid

(R)-2-Hydroxy-3-methylbutyric acid

methanol

Downstream raw materials:

methyl 2-benzyloxy-3-methylbutanoate

2,2-dimethyl-3-hydroxypropanaldehyde

2-(Benzyloxy)-3-methylbutanal

2-Benzyloxy-3-methyl-butan-1-ol