5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

Base Information

• Chemical Name: 5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine
• CAS No.: 1610610-31-5
• Molecular Formula: C₂₁H₁₆F₃N₃O
• Molecular Weight: 383.373
• Mol file: 1610610-31-5.mol

Synonyms:5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

Chemical Property of 5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

There total 6 articles about 5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-pyridin-2-ol (1003-68-5,91914-06-6) + 5-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine (1610612-12-8) → 5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine (1610610-31-5)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid (1610611-83-0) → 5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine (1610610-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 50 °C

2: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C

3: phosphorus tribromide / dichloromethane / 2 h / 20 °C

4: caesium carbonate / acetonitrile / 1 h / 20 °C

With thionyl chloride; phosphorus tribromide; diisobutylaluminium hydride; caesium carbonate; In dichloromethane; toluene; acetonitrile;

Reference yield:

4-pyridinecarboxylic acid, methyl ester (2459-09-8) → 5-(((5-methylpyridin-2-yl)oxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine (1610610-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / N,N-dimethyl-formamide / 40 °C

1.2: 100 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C

3.1: phosphorus tribromide / dichloromethane / 2 h / 20 °C

4.1: caesium carbonate / acetonitrile / 1 h / 20 °C

With phosphorus tribromide; diisobutylaluminium hydride; caesium carbonate; O-(2,4-dinitrophenyl)hydroxylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid

5-methyl-pyridin-2-ol

5-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

4-pyridinecarboxylic acid, methyl ester