ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate

Base Information

Chemical Name:ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate
CAS No.:1604039-73-7
Molecular Formula:C₂₄H₃₉NO₃Si
Molecular Weight:417.664
Hs Code.:

Synonyms:ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate

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Chemical Property of ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate

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Technology Process of ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate

There total 4 articles about ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1604039-12-4
ethyl (2-bromopropyl)(2-methoxyphenyl)carbamate

: 159862-82-5
((triisopropylsilyl)ethynyl)magnesium bromide

: 1604039-73-7
ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate

Guidance literature:: With Bis<2-(N,N-dimethylamino)aethyl>aether; iron(II) bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; for 16h; Inert atmosphere; Glovebox;
DOI:10.1021/ol501087m

Reference yield:

: 3351-93-7
2-bromo-N-(2-methoxyphenyl)propanamide

: 1604039-73-7
ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 20 - 50 °C / Inert atmosphere; Glovebox

2: 2,6-dimethylpyridine / diethyl ether / 20 °C / Inert atmosphere; Glovebox

3: iron(II) bromide; Bis<2-(N,N-dimethylamino)aethyl>aether / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 16 h / 20 °C / Inert atmosphere; Glovebox

With 2,6-dimethylpyridine; borane-THF; Bis<2-(N,N-dimethylamino)aethyl>aether; iron(II) bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether;
DOI:10.1021/ol501087m

Reference yield:

: 1604039-17-9
N-(2-bromopropyl)-2-methoxyaniline

: 1604039-73-7
ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / diethyl ether / 20 °C / Inert atmosphere; Glovebox

2: iron(II) bromide; Bis<2-(N,N-dimethylamino)aethyl>aether / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 16 h / 20 °C / Inert atmosphere; Glovebox

With 2,6-dimethylpyridine; Bis<2-(N,N-dimethylamino)aethyl>aether; iron(II) bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether;
DOI:10.1021/ol501087m