(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester
• CAS No.: 769969-24-6
• Molecular Formula: C₂₂H₃₂N₂O₈
• Molecular Weight: 452.505
• Mol file: 769969-24-6.mol

Synonyms:(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester

Chemical Property of (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester

There total 2 articles about (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.2%

bromoacetic acid tert-butyl ester (5292-43-3) + (L)-p-Nitrophenylalanine methyl ester (81677-60-3) → (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester (769969-24-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 70 ℃;

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester (769969-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; nitric acid / 1 h / 0 °C

2.1: potassium carbonate / acetonitrile / 0.5 h / Inert atmosphere

2.2: 18 h / Inert atmosphere; Reflux

With sulfuric acid; nitric acid; potassium carbonate; In acetonitrile;

DOI:10.1016/j.ejmech.2014.05.046

Reference yield:

(S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester (769969-24-6) → C22H34N2O6

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.05.046

upstream raw materials:

bromoacetic acid tert-butyl ester

(L)-p-Nitrophenylalanine methyl ester

methyl (2S)-2-amino-3-phenylpropanoate

Downstream raw materials:

2,2',2''-(10-(2-(4-(2-(bis(carboxymethyl)amino)-3-methoxy-3-oxopropyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid