methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate

Base Information

• Chemical Name: methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate
• CAS No.: 1408186-64-0
• Molecular Formula: C₁₉H₁₈Cl₂N₂O₆S
• Molecular Weight: 473.334

Synonyms:methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate

Chemical Property of methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate

There total 5 articles about methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester (114676-47-0,775275-31-5,790644-51-8,754962-86-2) → methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate (1408186-64-0)

Guidance literature:

Multi-step reaction with 7 steps

1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0.33 h / 0 - 90 °C / Microwave irradiation

3: sodium hydrogencarbonate / methanol / 0.25 h / 90 °C / Microwave irradiation

4: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide / 90 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

7: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; sodium azide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate (1408186-47-9) → methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate (1408186-64-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 90 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

C13H15Cl2NO7S2 → methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate (1408186-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 90 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.08.028

upstream raw materials:

cis-hydroxy-D-proline

(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester

methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate

methyl (2R,4R)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1408186-64-0 methyl (2R,4R)-1-[(3,4-dichlorophenyl)sulfonyl]-4-((E)-3-(furan-2-yl)acrylamido)pyrrolidine-2-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send