methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate
CAS No.:1408186-47-9
Molecular Formula:C₁₂H₁₃Cl₂NO₅S
Molecular Weight:354.211
Hs Code.:

Synonyms:methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate

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Chemical Property of methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate

There total 3 articles about methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₄Cl₃NO₆S

: 1408186-47-9
methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In methanol; at 90 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 114676-47-0,775275-31-5,790644-51-8,754962-86-2
(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester

: 1408186-47-9
methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0.33 h / 0 - 90 °C / Microwave irradiation

3: sodium hydrogencarbonate / methanol / 0.25 h / 90 °C / Microwave irradiation

With dmap; di-isopropyl azodicarboxylate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In methanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 1408186-45-7
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

: 1408186-47-9
methyl (2R,4S)-1-((3,4-dichlorophenyl)sulfonyl)-4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0.33 h / 0 - 90 °C / Microwave irradiation

2: sodium hydrogencarbonate / methanol / 0.25 h / 90 °C / Microwave irradiation

With di-isopropyl azodicarboxylate; sodium hydrogencarbonate; triphenylphosphine; In methanol; toluene;
DOI:10.1016/j.ejmech.2012.08.028