((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester

Base Information

• Chemical Name: ((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester
• CAS No.: 157992-80-8
• Molecular Formula: C₁₆H₂₂O₃S
• Molecular Weight: 294.415
• Mol file: 157992-80-8.mol

Synonyms:((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester

Chemical Property of ((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester

There total 5 articles about ((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

thiophenol (108-98-5) + tert-butyl 2-(but-3-yn-1-yloxy)acetate (157992-79-5) → ((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester (157992-80-8)

Guidance literature:

With triethyl borane; In toluene; at 22 ℃;

DOI:10.1016/S0040-4039(00)78198-6

Reference yield:

thiophenol (108-98-5) + tert-butyl 2-(but-3-yn-1-yloxy)acetate (157992-79-5) → tert-butyl 2-(4-oxo-3-(phenylthio)butoxy)acetate + ((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester (157992-80-8)

Guidance literature:

With tert.-butylhydroperoxide; water; oxygen; In tetrahydrofuran; at 25 ℃; for 48h; Solvent; Time; Concentration; Temperature;

DOI:10.1021/acs.joc.5b00641

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → ((E)-4-Phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester (157992-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Bu₄NHSO₄, 40percent NaOH / benzene; H₂O

2: 93 percent / Et₃B / toluene / 22 °C

With sodium hydroxide; triethyl borane; tetra(n-butyl)ammonium hydrogensulfate; In water; toluene; benzene;

DOI:10.1016/S0040-4039(00)78198-6

upstream raw materials:

thiophenol

tert-butyl 2-(but-3-yn-1-yloxy)acetate

bromoacetic acid tert-butyl ester

Downstream raw materials:

Bis-phenylsulfanyl-((E)-4-phenylsulfanyl-but-3-enyloxy)-acetic acid tert-butyl ester