2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide

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Chemical Name:2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide
CAS No.:183989-01-7
Molecular Formula:C₅₄H₆₆N₂O₁₀SSi
Molecular Weight:963.277
Hs Code.:

2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide

Synonyms:2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide

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Chemical Property of 2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide

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Technology Process of 2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide

There total 7 articles about 2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 183988-98-9
(4aS,6R,7R,7aR)-5-Benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-ol

: 183989-00-6
2-Trimethylsilanyl-ethanesulfonic acid ((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-bromo-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-amide

: 183989-01-7
2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide

Guidance literature:: With potassium hexamethylsilazane; In N,N-dimethyl-formamide; at -40 - 20 ℃;
DOI:10.1021/ja960526c

Reference yield:

: 125486-96-6
2-(trimethylsilyl)ethanesulfonamide

: 183989-01-7
2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / bromine, aq. NaOH

2: 2.) NH₄I / 1.) CH₂Cl₂, 0 deg C, 2.) ethanol

3: 80 percent / KHMDS / dimethylformamide / -40 - 20 °C

With ammonium iodide; sodium hydroxide; bromine; potassium hexamethylsilazane; In N,N-dimethyl-formamide;
DOI:10.1021/ja960526c

Reference yield:

: 100-39-0
benzyl bromide

: 183989-01-7
2-Trimethylsilanyl-ethanesulfonic acid [(2R,4aR,6R,7R,8S,8aS)-6-((4aS,6R,7R,7aR)-5-benzhydryl-6-benzyloxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyrrol-7-yloxy)-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Bu₂SnO, 2.) CsF / 1.) MeOH, reflux, 2.) DMF

2: 80 percent / KHMDS / dimethylformamide / -40 - 20 °C

With potassium hexamethylsilazane; di(n-butyl)tin oxide; cesium fluoride; In N,N-dimethyl-formamide;
DOI:10.1021/ja960526c