(2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide

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Chemical Name:(2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide
CAS No.:1246468-84-7
Molecular Formula:C₃₈H₃₇N₇O₄
Molecular Weight:655.756
Hs Code.:

Synonyms:(2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide

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Chemical Property of (2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide

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Technology Process of (2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide

There total 6 articles about (2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246471-23-7
C₁₂H₁₁N₅

: 2752-38-7
(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

: 1246468-84-7
(2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 5192-03-0
5-amino-1H-indole

: 1246468-84-7
(2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / acetonitrile; tetrahydrofuran / 0 - 25 °C

2.1: lithium diisopropyl amide; Triisopropyl borate / tetrahydrofuran / 2 h / 0 - 25 °C

2.2: pH 3

3.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / Inert atmosphere; Reflux

4.1: hydrogenchloride / methanol / 25 °C / Cooling with ice

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 25 °C

With hydrogenchloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Triisopropyl borate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 3.1: |Suzuki Coupling;

Reference yield:

: 253782-96-6
5-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonyl)indole

: 1246468-84-7
(2S)-1-(phenylacetyl)-N-{2-[5-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]pyrimidin-5-yl}pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide; Triisopropyl borate / tetrahydrofuran / 2 h / 0 - 25 °C

1.2: pH 3

2.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / Inert atmosphere; Reflux

3.1: hydrogenchloride / methanol / 25 °C / Cooling with ice

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 25 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Triisopropyl borate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;