Pyrido[3,2-d]pyrimidine-6-carboxylic acid, 2-amino-1,4-dihydro-4-oxo- (9CI)

Base Information

• Chemical Name: Pyrido[3,2-d]pyrimidine-6-carboxylic acid, 2-amino-1,4-dihydro-4-oxo- (9CI)
• CAS No.: 78711-31-6
• Molecular Formula: C₈H₆N₄O₃
• Molecular Weight: 206.161
• Mol file: 78711-31-6.mol

Synonyms:Pyrido[3,2-d]pyrimidine-6-carboxylicacid, 2-amino-1,4-dihydro-4-oxo- (9CI); NSC 302059

Chemical Property of Pyrido[3,2-d]pyrimidine-6-carboxylic acid, 2-amino-1,4-dihydro-4-oxo- (9CI)

Chemical Property:

• PSA: 122.95000
• LogP: -0.05910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[3,2-d]pyrimidine-6-carboxylic acid, 2-amino-1,4-dihydro-4-oxo- (9CI)

There total 3 articles about Pyrido[3,2-d]pyrimidine-6-carboxylic acid, 2-amino-1,4-dihydro-4-oxo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

2-amino-6-methyl-4-(3H)-pyrido<3,2-d>pyrimidinone (78711-30-5) → 2-amino-4(3H)-oxopyrido<3,2-d>pyrimidine-6-carboxylic acid (78711-31-6)

Guidance literature:

With sodium hydroxide; potassium permanganate; for 1h; Heating;

DOI:10.1021/jm00142a025

Reference yield:

2,4-dichloropyrido<3,2-d>pyrimidine (30212-52-3) → 2-amino-4(3H)-oxopyrido<3,2-d>pyrimidine-6-carboxylic acid (78711-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / 1 N aq. NaOH / 5 h / Ambient temperature

2: 75 percent / ammonia / ethanol / 18 h / 135 °C

3: 29 percent / aq. NaOH, aq. KMnO₄ / 1 h / Heating

With sodium hydroxide; potassium permanganate; ammonia; In ethanol;

DOI:10.1021/jm00142a025

Reference yield:

2-chloro-6-methylpyrido<3,2-d>pyrimidin-4(3H)-one (78711-28-1) → 2-amino-4(3H)-oxopyrido<3,2-d>pyrimidine-6-carboxylic acid (78711-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / ammonia / ethanol / 18 h / 135 °C

2: 29 percent / aq. NaOH, aq. KMnO₄ / 1 h / Heating

With sodium hydroxide; potassium permanganate; ammonia; In ethanol;

DOI:10.1021/jm00142a025

upstream raw materials:

2-amino-6-methyl-4-(3H)-pyrido<3,2-d>pyrimidinone

2,4-dichloropyrido<3,2-d>pyrimidine

2-chloro-6-methylpyrido<3,2-d>pyrimidin-4(3H)-one

Refernces