Technology Process of C26H27ClFN3O3
There total 8 articles about C26H27ClFN3O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
palladium bis[bis(diphenylphosphino)ferrocene] dichloride;
at 70 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere
3.1: sulfuric acid / 1,2-dimethoxyethane; water
3.2: 0.83 h / 0 - 5 °C
3.3: 0.5 h / 0 °C
4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
4.2: 18 h / 90 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 70 °C
With
sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere
3.1: sulfuric acid / 1,2-dimethoxyethane; water
3.2: 0.83 h / 0 - 5 °C
3.3: 0.5 h / 0 °C
4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
4.2: 18 h / 90 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 70 °C
With
sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;