Technology Process of C20H22ClNO3
There total 5 articles about C20H22ClNO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium tri-t-butoxyaluminum hydride;
In
tetrahydrofuran; ethanol;
at -78 ℃;
for 3h;
Overall yield = 85 %; Overall yield = 185 mg; stereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tet.2014.02.033
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / Reflux; Inert atmosphere
1.2: 0 °C / Inert atmosphere
2.1: trimethylaluminum / dichloromethane / Inert atmosphere
3.1: methyllithium lithium bromide / -78 °C / Inert atmosphere
4.1: lithium tri-t-butoxyaluminum hydride / ethanol; tetrahydrofuran / 3 h / -78 °C / Inert atmosphere
With
thionyl chloride; methyllithium lithium bromide; trimethylaluminum; lithium tri-t-butoxyaluminum hydride;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.tet.2014.02.033
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trimethylaluminum / dichloromethane / Inert atmosphere
2: methyllithium lithium bromide / -78 °C / Inert atmosphere
3: lithium tri-t-butoxyaluminum hydride / ethanol; tetrahydrofuran / 3 h / -78 °C / Inert atmosphere
With
methyllithium lithium bromide; trimethylaluminum; lithium tri-t-butoxyaluminum hydride;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.tet.2014.02.033
