4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate

Base Information

Chemical Name:4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate
CAS No.:1613462-76-2
Molecular Formula:C₅₀H₅₇N₅O₉
Molecular Weight:872.031
Hs Code.:

4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate

Synonyms:4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate

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Chemical Property of 4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate

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Technology Process of 4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate

There total 17 articles about 4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₀H₅₅N₅O₉

: 1613462-76-2
4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In methanol; for 18h;

Reference yield:

: (R)-quinuclidin-3-yl carbonochloridate

: 1613462-76-2
4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 17 h / 0 - 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 4 h / 20 °C

5.1: triethylamine / methanol / 1 h / 20 °C

6.1: sodium tris(acetoxy)borohydride; acetic acid / methanol / 18 h

With pyridine; hydrogenchloride; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 100331-89-3
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one

: 1613462-76-2
4-(((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / tetrahydrofuran / 4 h / -20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

3.1: sodium iodide; sodium azide / N,N-dimethyl-formamide; water / 40 h / 80 °C

4.1: 2,5-dihydrotoluene; palladium 10% on activated carbon / ethanol / 2 h / 60 °C

4.2: 18 h / 20 °C

5.1: triethylamine / methanol / 1 h / 20 °C

6.1: sodium tris(acetoxy)borohydride; acetic acid / methanol / 18 h

With 2,6-dimethylpyridine; sodium azide; 2,5-dihydrotoluene; dimethylsulfide borane complex; palladium 10% on activated carbon; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; sodium iodide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;