5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester

Base Information

• Chemical Name: 5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester
• CAS No.: 151220-93-8
• Molecular Formula: C₂₄H₂₂F₄N₂O₅
• Molecular Weight: 494.443

Synonyms:5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester

Chemical Property of 5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester

Chemical Property:

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Technology Process of 5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester

There total 4 articles about 5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-(4,5-Dimethoxy-2-nitro-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester (151221-02-2) → 5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester (151220-93-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; Ambient temperature;

DOI:10.1016/S0040-4039(00)73676-8

Reference yield:

2-(4,5-dimethoxy-2-nitrophenyl)acetonitrile (17354-04-0) → 5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester (151220-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 30 min, 2.) -20 deg C, 1.5 h

2: 90 percent / H₂ / 10percent Pd/C) / ethyl acetate / Ambient temperature

With hydrogen; sodium hexamethyldisilazane; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/S0040-4039(00)73676-8

Reference yield:

ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate (94714-58-6) → 5-(2-Amino-4,5-dimethoxy-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester (151220-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 30 min, 2.) -20 deg C, 1.5 h

2: 90 percent / H₂ / 10percent Pd/C) / ethyl acetate / Ambient temperature

With hydrogen; sodium hexamethyldisilazane; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/S0040-4039(00)73676-8

upstream raw materials:

5-(4,5-Dimethoxy-2-nitro-phenyl)-6-ethoxy-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester

2-(4,5-dimethoxy-2-nitrophenyl)acetonitrile

ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

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