4-isopropylbutyrophenone

Base Information

• Chemical Name: 4-isopropylbutyrophenone
• CAS No.: 78575-06-1
• Molecular Formula: C13H18 O
• Molecular Weight: 190.28142
• Mol file: 78575-06-1.mol

Synonyms:Butyrophenone,4'-isopropyl- (6CI)

Chemical Property of 4-isopropylbutyrophenone

Chemical Property:

• PSA: 17.07000
• LogP: 3.69560

Purity/Quality:

98% ^*data from raw suppliers

1-(4-Isopropyl-phenyl)-butan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-isopropylbutyrophenone

There total 2 articles about 4-isopropylbutyrophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Isopropylbenzene (98-82-8) + butyryl chloride (141-75-3) → 1-(4-isopropyl-phenyl)-butan-1-one (78575-06-1)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 ℃; for 2h; Sealed tube; Inert atmosphere;

DOI:10.3987/COM-20-14321

Reference yield:

Isopropylbenzene (98-82-8) + butyryl chloride (141-75-3) → 1-(4-isopropyl-phenyl)-butan-1-one (78575-06-1) + 1-(2-Isopropyl-phenyl)-butan-1-one

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; at 20 - 25 ℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Reference yield:

1-(4-isopropyl-phenyl)-butan-1-one (78575-06-1) → 1-(4'-isopropylphenyl)-5-propyl-1H-tetrazole

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; hydroxylamine hydrochloride / methanol / 16 h / 20 °C / Inert atmosphere

2: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 16 h / 120 °C / Inert atmosphere

With diphenylphosphoranyl azide; hydroxylamine hydrochloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; toluene;

DOI:10.3987/COM-20-14321

upstream raw materials:

Isopropylbenzene

butyryl chloride

Downstream raw materials:

1-(4-isopropyl-phenyl)-butan-1-ol

α-<4-Isopropyl-phenyl>-butylamin

1-(4-Isopropyl-phenyl)-butane-1,2-dione dioxime

1-butyl-4-(1-methylethyl)benzene

Refernces

• 1、 Beger, J.,Thielemann, C.. "Synthesis of Some New 1-Phenylalkan-1,2-diondioximes". . p. 137 - 148. Retrieved 2007/10/02.