7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine

Base Information

Chemical Name:7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine
CAS No.:131403-83-3
Molecular Formula:C₂₅H₁₈N₂O₃S
Molecular Weight:426.496
Hs Code.:

Synonyms:7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine

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Chemical Property of 7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine

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Technology Process of 7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine

There total 8 articles about 7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 14254-57-0
4-(chlorocarbonyl)pyridine

: 131403-74-2
6-p-methoxyphenylpyrrolo<2,1-d><1,5>benzothiazepin-7(6H)-one

: 131403-83-3
7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine

Guidance literature:: 6-p-methoxyphenylpyrrolo<2,1-d><1,5>benzothiazepin-7(6H)-one; With potassium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

4-(chlorocarbonyl)pyridine; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/jm049402y

Reference yield:

: 43153-76-0
1-(2-mercaptophenyl)-pyrrole

: 131403-83-3
7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium, ethanol / 1.) 15 min., 2.) THF, 60 deg C, 5h

2: 92 percent / NaOH / aq. ethanol / 5 h / Heating

3: 1.) PCl₅, 2.) AlCl₃ / 1.) CS₂, 65 deg C, 6h, 2.) CH₂Cl₂, 55-60 deg C, 23h

4: 1.) KH, 2.) triethylamine / 1.) THF, 5h, r.t., 2.) THF

With sodium hydroxide; aluminium trichloride; ethanol; phosphorus pentachloride; sodium; potassium hydride; triethylamine; In ethanol;

Reference yield:

: 14062-18-1
ethyl p-methoxyphenylacetate

: 131403-83-3
7-isonicotinoyloxy-6-p-methoxyphenylpyrrolo<2,1-d><1,5>-benzothiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / N-bromosucchinimide / CCl₄ / 25 h / Heating

2: 1.) sodium, ethanol / 1.) 15 min., 2.) THF, 60 deg C, 5h

3: 92 percent / NaOH / aq. ethanol / 5 h / Heating

4: 1.) PCl₅, 2.) AlCl₃ / 1.) CS₂, 65 deg C, 6h, 2.) CH₂Cl₂, 55-60 deg C, 23h

5: 1.) KH, 2.) triethylamine / 1.) THF, 5h, r.t., 2.) THF

With sodium hydroxide; N-Bromosuccinimide; aluminium trichloride; ethanol; phosphorus pentachloride; sodium; potassium hydride; triethylamine; In tetrachloromethane; ethanol;