12-nitro-(20S)-camptothecin

Base Information

Chemical Name:12-nitro-(20S)-camptothecin
CAS No.:58546-27-3
Molecular Formula:C₂₀H₁₅N₃O₆
Molecular Weight:393.356
Hs Code.:

Synonyms:12-nitro-(20S)-camptothecin

Suppliers and Price of 12-nitro-(20S)-camptothecin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 12-nitro-(20S)-camptothecin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 12-nitro-(20S)-camptothecin

There total 1 articles about 12-nitro-(20S)-camptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.8%

: 7689-03-4,91926-09-9
camptothecin

: 91421-42-0
rubitecan

: 58546-27-3
12-nitro-(20S)-camptothecin

Guidance literature:: With sulfuric acid; nitric acid; for 72h; Ambient temperature;
DOI:10.1248/cpb.39.3183

Reference yield: 93.1%

: 58546-27-3
12-nitro-(20S)-camptothecin

: 58546-28-4
12-amino-20(S)-camptothecin

Guidance literature:: With hydrogen; platinum(IV) oxide; In 1,4-dioxane; ethanol; for 2h; under 760 Torr;
DOI:10.1248/cpb.39.3183

Reference yield:

: 58546-27-3
12-nitro-(20S)-camptothecin

: 58546-25-1
12-chlorocamptothecin

Guidance literature:: Multi-step reaction with 2 steps

1: 93.1 percent / H₂ / PtO₂ / ethanol; dioxane / 2 h / 760 Torr

2: 1.) 14percent aq. HCl, aq. NaNO₂, 2.) CuCl, 18percent aq. HCl / 1.) 0-5 deg C, 2.) 60-70 deg C, 1 h

With hydrogenchloride; hydrogen; copper(l) chloride; sodium nitrite; platinum(IV) oxide; In 1,4-dioxane; ethanol;
DOI:10.1248/cpb.39.3183