1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,7-amino-4-ethyl-4-hydroxy-, (4S)-

Base Information

Chemical Name:1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,7-amino-4-ethyl-4-hydroxy-, (4S)-
CAS No.:58546-28-4
Molecular Formula:C20H17N3O4
Molecular Weight:363.3667
Hs Code.:
DSSTox Substance ID:DTXSID10207260
Nikkaji Number:J448.369C
Wikidata:Q83081152
ChEMBL ID:CHEMBL76033
Mol file:58546-28-4.mol

Synonyms:12-Aminocamptothecin;58546-28-4;1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,7-amino-4-ethyl-4-hydroxy-, (4S)-;12-Amino-20(S)-camptohecin;12-Amino-20(S)-camptothecin;CHEMBL76033;SCHEMBL7677097;DTXSID10207260;NSC603073;NSC-603073;1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)- dione, 7-amino-4-ethyl-4-hydroxy-, (S)-

Suppliers and Price of 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,7-amino-4-ethyl-4-hydroxy-, (4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,7-amino-4-ethyl-4-hydroxy-, (4S)-

Chemical Property:

Boiling Point:819.6°Cat760mmHg
Flash Point:449.5°C
PSA：107.44000
Density:1.55g/cm³
LogP:2.24300
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:363.12190603
Heavy Atom Count:27
Complexity:775

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C(=C4)C=CC=C5N)O
Isomeric SMILES:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C(=C4)C=CC=C5N)O

Technology Process of 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,7-amino-4-ethyl-4-hydroxy-, (4S)-

There total 2 articles about 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,7-amino-4-ethyl-4-hydroxy-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 58546-27-3
12-nitro-(20S)-camptothecin

: 58546-28-4
12-amino-20(S)-camptothecin

Guidance literature:: With hydrogen; platinum(IV) oxide; In 1,4-dioxane; ethanol; for 2h; under 760 Torr;
DOI:10.1248/cpb.39.3183

Reference yield:

: 19685-10-0
10-methoxycamptothecin

: 58546-28-4
12-amino-20(S)-camptothecin

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / conc. H₂SO₄, HNO₃ / 0.5 h / 0 °C

2: 82 percent / conc. HCl, Sn, SnCl₂*2H₂O / ethanol / 1.5 h / -7 °C

With hydrogenchloride; tin; sulfuric acid; nitric acid; tin(ll) chloride; In ethanol;
DOI:10.1021/jm00161a035

Reference yield:

: 58546-28-4
12-amino-20(S)-camptothecin

: 58546-25-1
12-chlorocamptothecin

Guidance literature:: With hydrogenchloride; copper(l) chloride; sodium nitrite; Yield given. Multistep reaction; 1.) 0-5 deg C, 2.) 60-70 deg C, 1 h;
DOI:10.1248/cpb.39.3183