2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine

Base Information

Chemical Name:2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine
CAS No.:1589541-12-7
Molecular Formula:C₃₅H₃₀ClIN₄O
Molecular Weight:685.007
Hs Code.:

Synonyms:2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine

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Chemical Property of 2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine

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Technology Process of 2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine

There total 2 articles about 2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1589541-11-6
(E)-2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N,N-dimethylethenamine

: 2393-23-9
4-methoxy-benzylamine

: 1589541-12-7
2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine

Guidance literature:: (E)-2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N,N-dimethylethenamine; 4-methoxy-benzylamine; In ethanol; acetic acid; 1,2-dichloro-ethane; at 85 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In ethanol; acetic acid; 1,2-dichloro-ethane; at 20 ℃; for 6h;

Reference yield:

: 6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridine

: 1589541-12-7
2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 12 h / 125 °C

2.1: ethanol; 1,2-dichloro-ethane; acetic acid / 3 h / 85 °C

2.2: 6 h / 20 °C

In ethanol; acetic acid; 1,2-dichloro-ethane;

Reference yield:

: 1589541-12-7
2-(6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-yl)-N-(4-methoxybenzyl)ethanamine

: 1589537-42-7
(R)-1-(1-phenylethyl)-3-(1,3,4,5-tetrahydropyrazolo[3,4,5-de][1,6]naphthyridin-7-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-(2-dicyclohexylphosphino-2′,6′-diiso-propoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane; tetrahydrofuran / 1 h / 55 °C / Inert atmosphere

2.1: caesium carbonate; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II) / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

3.1: trifluoroacetic acid / 0.5 h / 20 °C

3.2: 0.75 h / 20 - 80 °C

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); chloro-(2-dicyclohexylphosphino-2′,6′-diiso-propoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; caesium carbonate; trifluoroacetic acid; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane;