1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone

Base Information

• Chemical Name: 1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone
• CAS No.: 1206594-13-9
• Molecular Formula: C₁₉H₂₉BN₂O₃
• Molecular Weight: 344.262

Synonyms:1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone

Chemical Property of 1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4-((4-Acetylpiperazine)methyl)phenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

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Technology Process of 1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone

There total 1 articles about 1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetylpiperidine (13889-98-0) + 4-bromomethylphenylboronic acid pinacol ester (138500-85-3) → 1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone (1206594-13-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 41.0%

1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone (1206594-13-9) + (S)-3-(1-((4-(5-bromopyrimidin-2-yl)morpholine-2-yl)methyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)benzonitrile → (S)-3-(1-((4-(5-(4-((4-acetylpiperazin-1-yl)methyl)phenyl)pyrimidin-2-yl)morpholin-2-yl)methyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)benzonitrile

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

5-bromo-3-(1H-indol-5-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (1229583-70-3) + 1-(4-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethanone (1206594-13-9) → 1-(4-{4-[3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzyl}-piperazin-1-yl)-ethanone (1229583-41-8)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 150 ℃; for 0.333333h; Microwave irradiation;

upstream raw materials:

N-acetylpiperidine

4-bromomethylphenylboronic acid pinacol ester

Downstream raw materials:

1-(4-{4-[3-(1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzyl}-piperazin-1-yl)-ethanone

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