(E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene

Base Information

• Chemical Name: (E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene
• CAS No.: 38454-59-0
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.232
• Mol file: 38454-59-0.mol

Synonyms:(E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene

Chemical Property of (E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene

There total 14 articles about (E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(but-1-en-2-yl)-2-methoxybenzene → (E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene (38454-59-0)

Guidance literature:

With (PPO)FeCl₂; sodium triethylborohydride; In tetrahydrofuran; pentane; at 20 ℃; for 2h; stereoselective reaction; Inert atmosphere; Glovebox; Sealed tube; Schlenk technique;

DOI:10.1002/cjoc.202000492

Reference yield: 57.0%

α-methyl-α-ethyl-o-methoxybenzyl alcohol (53847-37-3) → (E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene (38454-59-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 1h; Heating;

Reference yield:

3-(3-Methoxy-phenyl)-buta-1,2-dien → (Z)-1-Methoxy-2-(1-methyl-1-propenyl)benzene (38454-58-9) + (E)-1-Methoxy-2-(1-methyl-1-propenyl)benzene (38454-59-0)

Guidance literature:

With tetrahydroxydiboron; 5%-palladium/activated carbon; water; In diethyl ether; at 20 ℃; for 5h; Overall yield = 72 percentSpectr.; stereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0039-1690207

upstream raw materials:

4-methoxyphenyl magnesium bromide

butanone

α-methyl-α-ethyl-o-methoxybenzyl alcohol

2-Methoxyacetophenone

Downstream raw materials:

3-(2'-Methoxyphenyl)thiophene

3-(2'-Hydroxyphenyl)thiophene

o-s-butylanisole

Refernces

• 1、 Hu, Xiao-Si,He, Jun-Xiong,Zhang, Ying,Zhou, Jian,Yu, Jin-Sheng. "Highly Stereoselective Positional Isomerization of Styrenes via Acid-Catalyzed Carbocation Mechanism". supporting information. p. 2227 - 2233. Retrieved 2021/06/28.
• 2、 Nguyen, T. N. Thanh,Thiel, Niklas O.,Pape, Felix,Teichert, Johannes F.. "Copper(I)-Catalyzed Allylic Substitutions with a Hydride Nucleophile". . p. 2455 - 2458. Retrieved 2016/06/09.