RG₆₀₈₀

Base Information

• Chemical Name: RG₆₀₈₀
• CAS No.: 1452458-86-4
• Molecular Formula: C₉H₁₆N₄O₇S
• Molecular Weight: 324.315
• Mol file: 1452458-86-4.mol

Synonyms:RG₆₀₈₀

Chemical Property of RG₆₀₈₀

Chemical Property:

• Density: 1.71±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Op-0595 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of RG₆₀₈₀

There total 76 articles about RG₆₀₈₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

{2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium (1501977-14-5) → RG6080 (1452458-86-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at -20 - 0 ℃; for 2h; Temperature; Inert atmosphere; Large scale;

Reference yield:

(2S,5R)-5-hydroxypiperidine-2-carboxylic acid (63088-78-8,448964-01-0,478409-64-2) → RG6080 (1452458-86-4)

Guidance literature:

Multi-step reaction with 11 steps

1.1: hydrogenchloride / 3 h / Reflux

2.1: triethylamine / tetrahydrofuran / 2.17 h / 10 - 20 °C / Cooling with ice

3.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / acetonitrile / 0.67 h / -36 - -30 °C

3.2: 48 h / -32 - 4 °C

4.1: hydrogenchloride / methanol / 72 h / Reflux

5.1: potassium carbonate / ethyl acetate; water

6.1: triethylamine / acetonitrile / 0.33 h / 2 - 5 °C / Cooling with ice

6.2: 10 h / 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 2.17 h / 2 - 4.9 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

9.1: palladium 10% on activated carbon; hydrogen / water; methanol / 0.75 h / 20 °C

10.1: 2,6-dimethylpyridine; sulfur trioxide pyridine complex / dichloromethane / 20 °C

10.2: 0.17 h

11.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Cooling with ice

With 2,6-dimethylpyridine; hydrogenchloride; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; water; hydrogen; sulfur trioxide pyridine complex; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

tert-butyl {2-[({[(2S,5R)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamate (1452467-93-4) → RG6080 (1452458-86-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

upstream raw materials:

{2-[({[(2S,5R)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester

{2-[({[(2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester

tert-butyl {2-[({[(2S,5R)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamate

(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid