bromodifluoromethylphenylacetylene

Base Information

• Chemical Name: bromodifluoromethylphenylacetylene
• CAS No.: 82477-43-8
• Molecular Formula: C₉H₅BrF₂
• Molecular Weight: 231.04
• Mol file: 82477-43-8.mol

Synonyms:bromodifluoromethylphenylacetylene

Chemical Property of bromodifluoromethylphenylacetylene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of bromodifluoromethylphenylacetylene

There total 6 articles about bromodifluoromethylphenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dibromodifluoromethane (75-61-6) + phenylacetylene (536-74-3) → bromodifluoromethylphenylacetylene (82477-43-8)

Guidance literature:

phenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

dibromodifluoromethane; In ethanol; hexane; at -100 - -50 ℃;

DOI:10.1021/ol052816g

Reference yield: 47.0%

(bromodifluoromethyl)diphenylsulfonium trifluoromethanesulfonate (1231894-78-2) + phenylacetylene (536-74-3) → bromodifluoromethylphenylacetylene (82477-43-8)

Guidance literature:

phenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

(bromodifluoromethyl)diphenylsulfonium trifluoromethanesulfonate; In tetrahydrofuran; hexane; Inert atmosphere; Cooling;

DOI:10.1055/s-0029-1219579

Reference yield:

dibromodifluoromethane (75-61-6) + phenylacetylene (536-74-3) → bromodifluoromethylphenylacetylene (82477-43-8) + 1-Bromo-2-phenylacetylene (932-87-6)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 2) THF, 1 h, -20 deg C; 1 h, 0 deg C; 4 h, RT;

DOI:10.1016/S0022-1139(00)80063-9

upstream raw materials:

halon-1211

phenylacetylene

dibromodifluoromethane

(bromodifluoromethyl)diphenylsulfonium trifluoromethanesulfonate

Downstream raw materials:

2,2-Difluoro-1-furan-2-yl-4-phenyl-but-3-yn-1-ol

4,4-Difluoro-1,6-diphenyl-hex-5-yn-3-ol

2,2-difluoro-1,4-diphenylbut-3-yn-1-ol

4,4-Difluoro-6-phenyl-hex-5-yn-3-ol

Refernces

• 1、 Urban, Celine,Cadoret, Frederic,Blazejewski, Jean-Claude,Magnier, Emmanuel. "Sulfoximines as a versatile scaffold for electrophilic fluoroalkylating reagents". experimental part. p. 4862 - 4867. Retrieved 2011/10/09.
• 2、 Surmont, Riccardo,Verniest, Guido,De Klmpe, Norbert. "Gold-catalyzed synthesis of 2-aryl-3-fluoropyrroles". scheme or table. p. 2920 - 2923. Retrieved 2009/12/05.