3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

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Chemical Name:3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt
CAS No.:610273-36-4
Molecular Formula:C₂₀H₁₄F₃N₃O₃
Molecular Weight:401.345
Hs Code.:

Synonyms:3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

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Chemical Property of 3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

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Technology Process of 3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

There total 5 articles about 3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 96-32-2
bromoacetic acid methyl ester

: 197515-04-1
3-hydroxy-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinoline

: 610273-36-4
3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1021/jo034160f

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 610273-36-4
3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / Et₃N / diethyl ether / 16 h / Heating

2: 81 percent / t-BuOH; NaH / toluene / 12 h / Heating

3: 48 percent / 4-toluenesulfonic acid hydrate / ethanol / 18 h / Heating

4: 96 percent / trifluoroacetic acid / 8 h / Heating

5: 46 percent / K₂CO₃ / dimethylformamide / 25 °C

With p-toluenesulfonic acid monohydrate; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; tert-butyl alcohol; In diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo034160f

Reference yield:

: 197516-50-0
methyl 2-{N-(methoxycarbonylmethyl)-N-[(4-methoxyphenyl)methyl]aminomethyl}benzoate

: 610273-36-4
3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / t-BuOH; NaH / toluene / 12 h / Heating

2: 48 percent / 4-toluenesulfonic acid hydrate / ethanol / 18 h / Heating

3: 96 percent / trifluoroacetic acid / 8 h / Heating

4: 46 percent / K₂CO₃ / dimethylformamide / 25 °C

With p-toluenesulfonic acid monohydrate; sodium hydride; potassium carbonate; trifluoroacetic acid; tert-butyl alcohol; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo034160f