5-hydroxy-5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cycloheptene-2,8-dicarboxamide

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Chemical Name:5-hydroxy-5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cycloheptene-2,8-dicarboxamide
CAS No.:1414932-69-6
Molecular Formula:C₂₉H₃₀N₆O₃
Molecular Weight:510.596
Hs Code.:

Synonyms:5-hydroxy-5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cycloheptene-2,8-dicarboxamide

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Chemical Property of 5-hydroxy-5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cycloheptene-2,8-dicarboxamide

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Technology Process of 5-hydroxy-5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cycloheptene-2,8-dicarboxamide

There total 2 articles about 5-hydroxy-5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cycloheptene-2,8-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

: 1414932-65-2
10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cyclohepten-5-one-2,8-dicarboxamide

: 6926-50-7
1-benzyl-1H-tetrazole

: 1414932-69-6
5-hydroxy-5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cycloheptene-2,8-dicarboxamide

Guidance literature:: 10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cyclohepten-5-one-2,8-dicarboxamide; 1-benzyl-1H-tetrazole; With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl acetamide; at -30 - -26 ℃; for 2.25h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; N,N-dimethyl acetamide; at -30 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0032-1316737

Reference yield:

: 100-46-9
benzylamine

: 1414932-69-6
5-hydroxy-5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5H-dibenzo[α,δ]cycloheptene-2,8-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide; acetic acid / 17 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl acetamide / 2.25 h / -30 - -26 °C / Inert atmosphere

2.2: 1 h / -30 °C / Inert atmosphere

With sodium azide; potassium tert-butylate; acetic acid; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1055/s-0032-1316737