3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester
CAS No.:86131-43-3
Molecular Formula:C₁₈H₂₂O₃Se
Molecular Weight:365.331
Hs Code.:

Synonyms:3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester

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Chemical Property of 3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester

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Technology Process of 3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester

There total 5 articles about 3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 51414-48-3
dianion of 2-carbomethoxy cyclohexanone

: 86131-42-2,86131-48-8
E/Z-3-chloro-2-methyl-1-selenophenylpropene

: 86131-43-3
3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(00)81502-6

Reference yield:

: 81764-73-0
2-methyl-3-selenophenyl-2-propene oxide

: 86131-43-3
3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / sodium hydride / tetrahydrofuran / 18 h / Heating

2: collidine, mesyl chloride, lithium chloride / dimethylformamide / 5 h / Ambient temperature; addition at 15 deg C

3: neat (no solvent) / 82 - 85 °C / 0.01 Torr

4: 65 percent / tetrahydrofuran / 0 °C

With 2,3,5-trimethyl-pyridine; sodium hydride; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)81502-6

Reference yield:

: 23974-72-3
sodium phenylselenide

: 86131-43-3
3-((E)-2-Methyl-3-phenylselanyl-allyl)-2-oxo-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / ethanol / 1.5 h / 35 °C / addition at 0 deg C

2: 84 percent / sodium hydride / tetrahydrofuran / 18 h / Heating

3: collidine, mesyl chloride, lithium chloride / dimethylformamide / 5 h / Ambient temperature; addition at 15 deg C

4: neat (no solvent) / 82 - 85 °C / 0.01 Torr

5: 65 percent / tetrahydrofuran / 0 °C

With 2,3,5-trimethyl-pyridine; sodium hydride; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)81502-6