(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

Base Information

Chemical Name:(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane
CAS No.:884381-86-6
Molecular Formula:C₁₆H₁₉ClN₂O₃
Molecular Weight:322.791
Hs Code.:

Synonyms:(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

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Chemical Property of (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

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Technology Process of (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

There total 3 articles about (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143327-63-3
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(p-toluenesulfonyloxy)methyl]-1,3-dioxalane

: 884381-86-6
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

Guidance literature:: With potassium hydroxide; lithium hydroxide; In N,N-dimethyl-formamide; at 120 ℃; for 9h;
DOI:10.1016/j.bmc.2009.01.078

Reference yield:

: 82362-50-3
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone

: 884381-86-6
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

2: potassium hydroxide; lithium hydroxide / N,N-dimethyl-formamide / 9 h / 120 °C

With potassium hydroxide; lithium hydroxide; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene; butan-1-ol;

Reference yield:

: 67085-11-4
1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole

: 884381-86-6
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-4-(hydroxymethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; dimethyl sulfoxide; triethylamine

2: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

3: potassium hydroxide; lithium hydroxide / N,N-dimethyl-formamide / 9 h / 120 °C

With potassium hydroxide; lithium hydroxide; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In N,N-dimethyl-formamide; toluene; butan-1-ol; 1: Swern Oxidation;