5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Base Information

Chemical Name:5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
CAS No.:1035555-47-5
Molecular Formula:C₁₆H₁₄FIN₄O₃
Molecular Weight:456.215
Hs Code.:

Synonyms:5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Chemical Property of 5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Technology Process of 5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

There total 5 articles about 5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1035556-19-4
C₂₁H₂₂FIN₄O₄

: 1035555-47-5
5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1286748-19-3
C₁₇H₁₇N₃O₆S

: 1035555-47-5
5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.bmcl.2011.01.071

Reference yield:

: 1122-67-4
6-(methylamino)pyrimidin-4(3H)-one

: 1035555-47-5
5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: 1-methyl-pyrrolidin-2-one; diphenylether / 240 °C

3: triethylamine / acetonitrile

4: lithium diisopropyl amide / tetrahydrofuran / -78 °C

With potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diphenylether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.071