diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride

Base Information

• Chemical Name: diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride
• CAS No.: 1393737-23-9
• Molecular Formula: C₂₂H₂₇NO₄*ClH
• Molecular Weight: 405.922
• Mol file: 1393737-23-9.mol

Synonyms:diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride

Chemical Property of diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride

There total 2 articles about diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

diethyl (S)-(α-methylbenzyl)aminomalonate + benzyl bromide (100-39-0) → diethyl 2-(N-benzyl-N-((S)-α-methylbenzyl)amino)malonate hydrochloride + diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride (1393737-23-9)

Guidance literature:

diethyl (S)-(α-methylbenzyl)aminomalonate; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Cooling with ice;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

DOI:10.1016/j.tet.2012.06.090

Reference yield: 39.0%

diethyl (S)-(α-methylbenzyl)aminomalonate + benzyl chloride (100-44-7) → diethyl 2-(N-benzyl-N-((S)-α-methylbenzyl)amino)malonate hydrochloride + diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride (1393737-23-9)

Guidance literature:

diethyl (S)-(α-methylbenzyl)aminomalonate; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Cooling with ice;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

DOI:10.1016/j.tet.2012.06.090

Reference yield: 100.0%

diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate hydrochloride (1393737-23-9) → diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate (1393737-24-0)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; water; Saturated solution;

DOI:10.1016/j.tet.2012.06.090

upstream raw materials:

benzyl bromide

benzyl chloride

Downstream raw materials:

diethyl 2-benzyl-2-(N-((S)-α-methylbenzyl)amino)malonate

(S)-2-benzyl-2-((α-methylbenzyl)amino)-1,3-propanediol

(4R,αS)-4-benzyl-4-hydroxymethyl-3-(α-methylbenzyl)-2-oxazolidinone

(4S,αS)-4-benzyl-4-hydroxymethyl-3-(α-methylbenzyl)-2-oxazolidinone