3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine
CAS No.:1285456-60-1
Molecular Formula:C₁₃H₁₄ClF₂N₃O₄
Molecular Weight:349.722
Hs Code.:

Synonyms:3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine

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Chemical Property of 3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine

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Technology Process of 3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine

There total 4 articles about 3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 2375-76-0
1-chloro-1,1-difluoropentane-2,4-dione

: 30597-39-8
5-Aminoimidazole ribonucleoside

: 1285456-60-1
3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: In N,N-dimethyl-formamide; at 60 - 80 ℃; Inert atmosphere;
DOI:10.1021/jo102579g

Reference yield: 8.0%

: 2375-76-0
1-chloro-1,1-difluoropentane-2,4-dione

: potassium 5-amino-1-(β-D-ribofuranosyl)-4-imidazolecarboxylate

: 1285456-60-1
3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: potassium 5-amino-1-(β-D-ribofuranosyl)-4-imidazolecarboxylate; With acetic acid; In dimethyl sulfoxide;

1-chloro-1,1-difluoropentane-2,4-dione; In dimethyl sulfoxide; at 60 - 80 ℃; Inert atmosphere;
DOI:10.1021/jo102579g

Reference yield:

: 2375-76-0
1-chloro-1,1-difluoropentane-2,4-dione

: 1285456-60-1
3-(β-D-ribofuranosyl)-7-(chloro(difluoro)methyl)-5-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 1.33 h / Inert atmosphere; Reflux

1.2: 20 °C / Reflux

2.1: trifluoroacetic acid / 20 °C

3.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.33 h / Inert atmosphere; Reflux

3.2: 2 h / Reflux

4.1: methanol; ammonia / 24 h / 20 °C

With methanol; N,O-bis-(trimethylsilyl)-acetamide; ammonia; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jo102579g