Technology Process of (4R)-4-benzyl-3-[(2R)-2-methylpentanoyl]-1,3-oxazolidin-2-one
There total 1 articles about (4R)-4-benzyl-3-[(2R)-2-methylpentanoyl]-1,3-oxazolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4R)-3-(1-oxopentyl)-4-phenylmethyloxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 2.5h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran;
at -78 ℃;
for 4.08333h;
Inert atmosphere;
DOI:10.1021/jm900229p
- Guidance literature:
-
(4R)-4-benzyl-3-[(2R)-2-methylpentanoyl]-1,3-oxazolidin-2-one;
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 ℃;
for 2.5h;
Inert atmosphere;
With
water;
In
diethyl ether;
for 0.833333h;
Cooling with ice;
DOI:10.1021/jm900229p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hydroxide monohydrate; water; dihydrogen peroxide / tetrahydrofuran / 0 - 25 °C / Inert atmosphere
2.1: triethylamine / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere
3.1: tetrahydrofuran / 16 h / 20 - 25 °C / Inert atmosphere
4.1: diethyl ether / 0 - 25 °C / Inert atmosphere
5.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - -50 °C / Inert atmosphere
5.2: 3.17 h / -78 °C / Inert atmosphere
With
lithium hydroxide monohydrate; water; dihydrogen peroxide; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/ol2007567
