methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate

Base Information

Chemical Name:methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate
CAS No.:1551577-12-8
Molecular Formula:C₁₉H₁₈Cl₂FNO₄
Molecular Weight:414.261
Hs Code.:

Synonyms:methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate

Chemical Property:

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Technology Process of methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate

There total 7 articles about methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₁Cl₃O₃

: 450-91-9
4-fluoro-2-methoxyaniline

: 1551577-12-8
methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate

Guidance literature:: With dmap; triethylamine; In chloroform; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2013.11.053

Reference yield:

: C₁₃H₉Cl₂F₃O₅

: 1551577-12-8
methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 0 - 20 °C

2: N,N-dimethyl-formamide; oxalyl dichloride / chloroform / 1 h / 0 - 20 °C

3: triethylamine; dmap / chloroform / 0 - 20 °C

With dmap; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In chloroform;
DOI:10.1016/j.bmc.2013.11.053

Reference yield:

: 74299-82-4
dimethyl 2-(2,4-dichlorobenzylidene)malonate

: 1551577-12-8
methyl 3-(2,4-dichlorophenyl)-5-((4-fluoro-2-methoxyphenyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate / methanol / 1 h / 20 °C

2: hydrogenchloride; water / Reflux

3: chloroform / 0 - 20 °C

4: triethylamine / 0 - 20 °C

5: N,N-dimethyl-formamide; oxalyl dichloride / chloroform / 1 h / 0 - 20 °C

6: triethylamine; dmap / chloroform / 0 - 20 °C

With hydrogenchloride; dmap; oxalyl dichloride; water; sodium methylate; triethylamine; N,N-dimethyl-formamide; In methanol; chloroform; 1: |Michael Addition;
DOI:10.1016/j.bmc.2013.11.053