7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

Base Information

Chemical Name:7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one
CAS No.:1448441-86-8
Molecular Formula:C₂₀H₁₄F₂IN₃O₄S
Molecular Weight:557.316
Hs Code.:

Synonyms:7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

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Chemical Property of 7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

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Technology Process of 7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

There total 9 articles about 7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2822-41-5
2,3,4-trifluorophenol

: 1448441-86-8
7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / acetone / 24 h / 50 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

4.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

7.1: toluene-4-sulfonic acid / 1 h

8.1: N-iodo-succinimide; trifluoroacetic acid / N,N-dimethyl-formamide / 5 h / 20 °C

9.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 3 h / Reflux

10.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C

With dmap; N-iodo-succinimide; n-butyllithium; sodium azide; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 392309-26-1
1-(Benzyloxy)-2,3,4-trifluorobenzene

: 1448441-86-8
7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

3.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 5 h / 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

6.1: toluene-4-sulfonic acid / 1 h

7.1: N-iodo-succinimide; trifluoroacetic acid / N,N-dimethyl-formamide / 5 h / 20 °C

8.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 3 h / Reflux

9.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C

With dmap; N-iodo-succinimide; n-butyllithium; sodium azide; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 5-benzyloxy-2,3,4-trifluorobenzoic acid

: 1448441-86-8
7-((1-allylcyclopropyl)sulfonyl)-4-fluoro-5-(2-fluoro-4-iodophenyl)-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

2: potassium hydrogencarbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

5: toluene-4-sulfonic acid / 1 h

6: N-iodo-succinimide; trifluoroacetic acid / N,N-dimethyl-formamide / 5 h / 20 °C

7: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 3 h / Reflux

8: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C

With dmap; N-iodo-succinimide; sodium azide; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;