4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester

Base Information

• Chemical Name: 4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester
• CAS No.: 678165-22-5
• Molecular Formula: C₄₄H₆₆O₁₂Si₂
• Molecular Weight: 843.172

Synonyms:4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester

Chemical Property of 4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester

There total 4 articles about 4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methoxy-benzoyl chloride (100-07-2) + (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-3-hydroxy-6-methoxy-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-ol (678165-20-3) → 4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester (678165-22-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1039/b307950c

Reference yield:

2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((R)-3-oxo-6-hydroxy-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-hydroxy-6H-pyran-3-one → 4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester (678165-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / BF₃*Et₂O / CH₂Cl₂ / 0.5 h / 20 °C

2: 98 percent / CeCl₃*7H₂O; NaBH₄ / ethanol / 6 h

3: 97 percent / Et₃N; DMAP / CH₂Cl₂ / 18 h / 20 °C

With dmap; sodium tetrahydroborate; cerium(III) chloride; boron trifluoride diethyl etherate; triethylamine; In ethanol; dichloromethane; 2: Luche reduction;

DOI:10.1039/b307950c

Reference yield:

2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((R)-3-oxo-6-methoxy-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-6H-pyran-3-one → 4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester (678165-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / CeCl₃*7H₂O; NaBH₄ / ethanol / 6 h

2: 97 percent / Et₃N; DMAP / CH₂Cl₂ / 18 h / 20 °C

With dmap; sodium tetrahydroborate; cerium(III) chloride; triethylamine; In ethanol; dichloromethane; 1: Luche reduction;

DOI:10.1039/b307950c

upstream raw materials:

4-methoxy-benzoyl chloride

(2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-3-hydroxy-6-methoxy-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-ol

(2R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((R)-3-oxo-6-methoxy-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-6H-pyran-3-one

Downstream raw materials:

(2R,3R,4R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R',3R',6R')-3'-(4-methoxybenzoyloxy)-6'-methoxy-3,6-dihydro-2H-pyran-2-yl)-butyl]-4-acetoxy-6-methoxy-3-(4-methoxybenzoyloxy)-tetrahydropyran

(2R,3R,4S,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R',3R',6R')-6'-methoxy-3'-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3-(4-methoxybenzoyloxy)-tetrahydropyran-4-ol

(2R,3R,4R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R',3R',6R')-3'-(4-methoxybenzoyloxy)-6'-methoxy-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3-(4-methoxybenzoyloxy)-tetrahydropyran-4-ol

(2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R',3R',6R')-3'-(4-methoxybenzoyloxy)-6'-methoxy-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3-(4-methoxybenzoyloxy)-tetrahydropyran-4-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 678165-22-5 4-methoxybenzoic acid (2R,3R,6R)-2-[(2R,3R)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-4-((2R,3R,6R)-6-methoxy-3-(4-methoxybenzoyloxy)-3,6-dihydro-2H-pyran-2-yl)-butyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send