Technology Process of (1R,4S,6R,10S)-3-Benzyl-9,10-dihydroxy-5,8-dioxa-3-aza-tricyclo[4.3.1.01,4]decan-2-one
There total 9 articles about (1R,4S,6R,10S)-3-Benzyl-9,10-dihydroxy-5,8-dioxa-3-aza-tricyclo[4.3.1.01,4]decan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium periodate; sodium hydrogencarbonate;
In
methanol; water;
for 72h;
Ambient temperature;
DOI:10.1016/0040-4020(89)80050-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) acetonitrile, 16 deg C, 2 h; 2.) acetonitrile, -30 -> r.t.
2: 51 percent / K2CO3 / tetrabutylammonium bromide / toluene / 3 h / Heating
3: 96 percent / H2 / Pd/C / methanol; ethyl acetate / 4 h / 2280 Torr / Ambient temperature
4: 82 percent / sodium metaperiodate, sodium hydrogencarbonate / methanol; H2O / 72 h / Ambient temperature
With
sodium periodate; hydrogen; sodium hydrogencarbonate; potassium carbonate;
palladium on activated charcoal; tetrabutylammomium bromide;
In
methanol; water; ethyl acetate; toluene;
DOI:10.1016/0040-4020(89)80050-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / 1 h
2: K2CO3 / tetrabutylammonium bromide / benzene / 2 h / Heating
3: MeOH, Dowex 50 Wx8 resin / 0.25 h
4: 82 percent / sodium metaperiodate, sodium hydrogencarbonate / methanol; H2O / 72 h / Ambient temperature
With
methanol; sodium periodate; Dowex 50 WX8 resin; sodium hydrogencarbonate; potassium carbonate;
tetrabutylammomium bromide;
In
pyridine; methanol; water; benzene;
DOI:10.1016/0040-4020(89)80050-X
