4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester

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Chemical Name:4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester
CAS No.:939777-49-8
Molecular Formula:C₂₂H₃₄N₂O₆
Molecular Weight:422.522
Hs Code.:

Synonyms:4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester

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Chemical Property of 4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester

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Technology Process of 4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester

There total 2 articles about 4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 939777-43-2
(S)-3-(2-hydroxy-1-phenylethylamino)-2,2-dimethyl-3-oxopropanoic acid

: 3-amino-4-hydroxy-butyric acid benzyl ester; compound with trifluoro-acetic acid

: 939777-49-8
4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester

Guidance literature:: With TEA; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; at 20 ℃; for 24h;
DOI:10.1016/j.jorganchem.2007.02.009

Reference yield:

: 13051-21-3
3-methoxy-2,2-dimethyl-3-oxopropanoic acid

: 939777-49-8
4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: EDC; HOBT / CHCl₃

1.2: 81 percent / NaOH / tetrahydrofuran; H₂O

2.1: 100 percent / EDC; HOBT; TEA / CHCl₃ / 24 h / 20 °C

With TEA; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform;
DOI:10.1016/j.jorganchem.2007.02.009

Reference yield: 53.0%

: 939777-49-8
4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester

: {2-[1-(4-tert-butyl-4,5-dihydro-oxazol-2-yl)-1-methyl-ethyl]-4,5-dihydro-oxazol-4-yl}-acetic acid benzyl ester

Guidance literature:: 4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester; With methanesulfonyl chloride; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

With dmap; triethylamine; In 1,2-dichloro-ethane; at 50 ℃; for 40h;
DOI:10.1016/j.jorganchem.2007.02.009