13051-21-3

Basic information

• Product Name: 2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER
• Synonyms: 2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER;3-Methoxy-2,2-diMethyl-3-oxopropanoic acid
• CAS NO: 13051-21-3
• Molecular Formula: C₆H₁₀O₄
• Molecular Weight: 146.1412
• Mol File: 13051-21-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 35-38 °C
• Boiling Point: 233.8ºC at 760 mmHg
• Flash Point: 94ºC
• Appearance: /
• Density: 1.162g/cm3
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.44
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.92±0.36(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER(13051-21-3)
• EPA Substance Registry System: 2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER(13051-21-3)

Safety Data

• Hazardous Substances Data: 13051-21-3(Hazardous Substances Data)

Usage

General Description

2,2-Dimethyl-Malonic Acid Monomethyl Ester is a synthetic chemical compound. It is an ester derivative of 2,2-Dimethylmalonic acid, commonly used in various chemical reactions and syntheses in the field of organic chemistry. 2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER falls under the category of malonic acids and derivatives. These compounds contain a structure derived from malonic acid (propanedioic acid), which is a dibasic acid characterized by two carboxylic acid (-COOH) groups. The physical properties of 2,2-Dimethyl-Malonic Acid Monomethyl Ester are yet to be fully characterized in scientific literature.

InChI:InChI=1/C6H10O4/c1-6(2,4(7)8)5(9)10-3/h1-3H3,(H,7,8)

Upstream product

• 6065-54-9 dimethyl dimethylmalonate 
• 141-52-6 sodium ethanolate 
• 67-56-1 methanol 
• 15568-97-5 2,2,5,5-tetramethyl-[1,3]dioxane-4,6-dione 
• 595-46-0 2,2-dimethylmalonic acid 
• 34867-85-1 4,4-dimethyl-1,2-dioxolane-3,5 -dione 
• 934733-52-5 methyl 2-dimethylbismuthanyl-2-methylpropanoate 
• 124-38-9 carbon dioxide 
• 38923-57-8 methyl 2,2-dimethyl-3-oxobutanoate 

Downstream Products

• 64507-20-6 2-chlorocarbonyl-2-methylpropionic acid methyl ester 
• 1188911-72-9 methyl 3,3,3-trifluoro-2,2-dimethylpropanoate 
• 194031-15-7 2,2-Dimethyl-malonic acid 2-((E)-2-ethoxycarbonyl-vinyl)-5-methoxy-phenyl ester methyl ester 
• 194031-20-4 (E)-5-[(2-Methoxycarbonyl-2-methyl-propionyl)-phenyl-amino]-pent-2-enoic acid ethyl ester 
• 194031-14-6 2,2-Dimethyl-malonic acid 2-((E)-2-ethoxycarbonyl-vinyl)-5-methyl-phenyl ester methyl ester 
• 194031-21-5 (E)-4-[(2-Methoxycarbonyl-2-methyl-propionyl)-phenyl-amino]-but-2-enoic acid ethyl ester 
• 194031-13-5 2,2-Dimethyl-malonic acid 2-((E)-2-ethoxycarbonyl-vinyl)-phenyl ester methyl ester 
• 194031-17-9 (E)-3-[2-(2-Methoxycarbonyl-2-methyl-propionylamino)-phenyl]-acrylic acid ethyl ester 
• 194031-18-0 N-But-3-enyl-2,2-dimethyl-N-phenyl-malonamic acid methyl ester 
• 194031-19-1 N-Allyl-2,2-dimethyl-N-phenyl-malonamic acid methyl ester 
• 939777-51-2 4-hydroxy-3-[2-(2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester 
• 939777-49-8 4-hydroxy-3-[2-(1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-2-methyl-propionylamino]-butyric acid benzyl ester 
• 939777-43-2 (S)-3-(2-hydroxy-1-phenylethylamino)-2,2-dimethyl-3-oxopropanoic acid 
• 547-63-7 Methyl isobutyrate 

Relevant articles and documents

Glycosylation enhances the anti-migratory activities of isomalyngamide A analogs

Three, new, fully synthetic glycosylated isomalyngamide A analogs 4-6 were prepared and evaluated for their anti-migratory activities in human breast cancer cells. The results of the study show that two glycosylated derivatives 4 and 5, containing mannose and galactose appendages, suppress metastatic events (e.g., migration, invasion and adhesion) in human breast adenocarcinoma MDA-MB-231 cells at "nontoxic" concentration levels. In contrast, derivative 6 that contains a lactose moiety, displays a less potent activity. The findings show that monosaccharide rather than disaccharide appendages to the isomalyngamide A backbone more greatly influence cell migration and invasive ability. Evidence has been gained for a mechanism for inhibition of metastatic activities in MDA-MB-231 cells by 4 and 5, involving inactivation of the expression of p-FAK and paxillin through the integrin-mediated antimetastatic pathway.

Spontaneous reaction of malonyl peroxides with methanol

The spontaneous reaction of disubstituted malonyl peroxides (MPOs) with methanol affording monopermalonic acid monomethyl esters is fast (minutes) for lower homologues but is sharply decelerated (days) for the higher ones. Spirocyclopropyl-MPO is an excep

Selective monoesterification of malonic acid catalyzed by boric acid

Boric acid catalyzes the monoesterification of malonic acid, likely through a chelation mechanism that is not available to the monoester product. Under more forcing conditions, diesters form to some extent, but conditions can be optimized to favour the monoester product (56?80%). With the easily handled solid acid catalyst, these reactions can be run with excess alcohol as solvent or with stoichiometric amounts of alcohol in acetonitrile with moderate heating. CSIRO 2007.