(R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

Base Information

Chemical Name:(R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid
CAS No.:1257388-26-3
Molecular Formula:C₂₁H₂₈N₂O₇
Molecular Weight:420.463
Hs Code.:

Synonyms:(R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

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Chemical Property of (R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

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Technology Process of (R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

There total 5 articles about (R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1257388-24-1
(R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

: 1257388-26-3
(R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 20 ℃;

Reference yield:

: 28544-93-6
[1,4]dioxepan-6-one

: 1257388-26-3
(R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydroxide / dichloromethane / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 1 h / 20 °C

4.1: water; lithium hydroxide / methanol / 20 °C

With N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1257388-20-7
(R)-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-5-one

: 1257388-26-3
(R)-2-(1-(tert-butoxycarbonyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 1 h / 20 °C

3.1: water; lithium hydroxide / methanol / 20 °C

With water; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;