(R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate
CAS No.:1257388-24-1
Molecular Formula:C₂₂H₃₀N₂O₇
Molecular Weight:434.489
Hs Code.:

Synonyms:(R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

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Chemical Property of (R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

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Technology Process of (R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

There total 4 articles about (R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1257388-22-9
(R)-tert-butyl 5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

: 96-32-2
bromoacetic acid methyl ester

: 1257388-24-1
(R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

Guidance literature:: (R)-tert-butyl 5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

bromoacetic acid methyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 65652-63-3
diethyl 2,2'-(ethane-1,2-diylbis(oxy))diacetate

: 1257388-24-1
(R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / tetrahydrofuran / 20 °C / Inert atmosphere; Reflux

1.2: pH 5 / Inert atmosphere

2.1: hydrogenchloride / water / 2.5 h / Reflux

3.1: N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydroxide / dichloromethane / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 1 h / 20 °C

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 88664-38-4
ethyl 6-oxo-1,4-dioxepane-5-carboxylate

: 1257388-24-1
(R)-tert-butyl 4-(2-methoxy-2-oxoethyl)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 2.5 h / Reflux

2.1: N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydroxide / dichloromethane / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 1 h / 20 °C

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;