Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester

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Chemical Name:Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester
CAS No.:764722-73-8
Molecular Formula:C₂₆H₃₃N₃O₅S
Molecular Weight:499.631
Hs Code.:

Synonyms:Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester

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Chemical Property of Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester

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Technology Process of Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester

There total 6 articles about Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5731-13-5
4-(4-ethylphenyl)benzoic acid

: 764722-73-8
Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: HBTU; HOBt; DIEA / dimethylformamide / 18 h / 20 °C

2: ammonium formate / Pd/C / ethanol / 2 h / Heating

3: TEA / tetrahydrofuran / 2 h / 0 - 20 °C

4: TEA / dimethylformamide / 4 h / 80 °C

5: TEA / CH₂Cl₂ / 1 h / -40 °C

With TEA; ammonium formate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.049

Reference yield:

: 764722-69-2
4'-Ethyl-biphenyl-4-carboxylic acid ((S)-1-benzyl-pyrrolidin-3-yl)-methyl-amide

: 764722-73-8
Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium formate / Pd/C / ethanol / 2 h / Heating

2: TEA / tetrahydrofuran / 2 h / 0 - 20 °C

3: TEA / dimethylformamide / 4 h / 80 °C

4: TEA / CH₂Cl₂ / 1 h / -40 °C

With TEA; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.049

Reference yield:

: 169749-99-9
(3S)-(-)-1-benzyl-3-(methylamino)pyrrolidine

: 764722-73-8
Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: HBTU; HOBt; DIEA / dimethylformamide / 18 h / 20 °C

2: ammonium formate / Pd/C / ethanol / 2 h / Heating

3: TEA / tetrahydrofuran / 2 h / 0 - 20 °C

4: TEA / dimethylformamide / 4 h / 80 °C

5: TEA / CH₂Cl₂ / 1 h / -40 °C

With TEA; ammonium formate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.049