4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide

Base Information

Chemical Name:4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide
CAS No.:764722-72-7
Molecular Formula:C₂₅H₃₁N₃O₃
Molecular Weight:421.539
Hs Code.:

Synonyms:4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide

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Chemical Property of 4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide

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Technology Process of 4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide

There total 1 articles about 4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5731-13-5
4-(4-ethylphenyl)benzoic acid

: 764722-72-7
4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: HBTU; HOBt; DIEA / dimethylformamide / 18 h / 20 °C

2: ammonium formate / Pd/C / ethanol / 2 h / Heating

3: TEA / tetrahydrofuran / 2 h / 0 - 20 °C

4: TEA / dimethylformamide / 4 h / 80 °C

With TEA; ammonium formate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.049

Reference yield:

: 764722-72-7
4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide

: 124-63-0
methanesulfonyl chloride

: 764722-73-8
Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester

Guidance literature:: With TEA; In dichloromethane; at -40 ℃; for 1h;
DOI:10.1016/j.bmcl.2006.06.049

Reference yield:

: 764722-72-7
4'-Ethyl-biphenyl-4-carboxylic acid [(S)-1-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide

: 4'-Ethyl-biphenyl-4-carboxylic acid {(S)-1-[(R)-3-((S)-1,2-dimethyl-propylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: TEA / CH₂Cl₂ / 1 h / -40 °C

2: N,N-dimethyl-acetamide / 24 h / 60 - 90 °C

With TEA; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2006.06.049