2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Base Information

• Chemical Name: 2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide
• CAS No.: 1395084-65-7
• Molecular Formula: C₁₈H₁₉NO₄
• Molecular Weight: 313.353
• Mol file: 1395084-65-7.mol

Synonyms:2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Chemical Property of 2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

There total 1 articles about 2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,3-benzodioxole-5-acetic acid (2861-28-1) + 4-Methoxyphenethylamine (55-81-2) → 2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide (1395084-65-7)

Guidance literature:

In neat (no solvent); at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1080/00397911.2011.642925

Reference yield: 47.0%

2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide (1395084-65-7) → (2-benzo[1,3]dioxol-5-ylethyl)[2-(4-methoxyphenyl)ethyl]amine (118425-61-9)

Guidance literature:

With lithium aluminium tetrahydride; In tert-butyl methyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm3006096

Reference yield:

2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide (1395084-65-7) → N-(4-methoxy-β-phenethyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (79133-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tert-butyl methyl ether / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / water; methanol / 3 h / Inert atmosphere; Reflux

With hydrogenchloride; lithium aluminium tetrahydride; In methanol; tert-butyl methyl ether; water;

DOI:10.1021/jm3006096

upstream raw materials:

1,3-benzodioxole-5-acetic acid

4-Methoxyphenethylamine

Downstream raw materials:

(2-benzo[1,3]dioxol-5-ylethyl)[2-(4-methoxyphenyl)ethyl]amine

N-(4-methoxy-β-phenethyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline