ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate

Base Information

Chemical Name:ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate
CAS No.:1417797-87-5
Molecular Formula:C₂₁H₂₁NO₅S₂
Molecular Weight:431.533
Hs Code.:

Synonyms:ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate

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Chemical Property of ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate

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Technology Process of ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate

There total 1 articles about ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: ethyl 5-(3-bromo-4-methoxyphenyl)-4-methylthiophene-2-carboxylate

: 613660-87-0
4-sulfamoylphenylboronic acid

: 1417797-87-5
ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate

Guidance literature:: ethyl 5-(3-bromo-4-methoxyphenyl)-4-methylthiophene-2-carboxylate; 4-sulfamoylphenylboronic acid; With potassium carbonate; In ethanol; toluene; at 25 ℃; for 0.25h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 90 - 95 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield: 99.3%

: 1417797-87-5
ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate

: 1417797-92-2
5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylic acid

Guidance literature:: ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate; With water; sodium hydroxide; In ethanol; at 25 - 85 ℃;

With hydrogenchloride; In water; at 0 ℃; pH=Ca. 1;

Reference yield:

: 1417797-87-5
ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate

: 1417797-96-6
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 25 - 85 °C

1.2: 0 °C / pH Ca_. 1

2.1: oxalyl dichloride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

With oxalyl dichloride; water; sodium hydroxide; In ethanol; dichloromethane;