5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

Base Information

Chemical Name:5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide
CAS No.:1417797-96-6
Molecular Formula:C₂₄H₂₇N₃O₅S₂
Molecular Weight:501.627
Hs Code.:

Synonyms:5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

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Chemical Property of 5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

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Technology Process of 5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

There total 4 articles about 5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.2%

: 1417797-92-2
5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1417797-96-6
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

Guidance literature:: 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylic acid; N,N-dimethyl-formamide; With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 613660-87-0
4-sulfamoylphenylboronic acid

: 1417797-96-6
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

1.2: 16 h / 90 - 95 °C / Inert atmosphere; Sealed tube

2.1: sodium hydroxide; water / ethanol / 25 - 85 °C

2.2: 0 °C / pH Ca_. 1

3.1: oxalyl dichloride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C

With oxalyl dichloride; water; potassium carbonate; sodium hydroxide; In ethanol; dichloromethane; toluene;

Reference yield:

: 1417797-87-5
ethyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-4-methylthiophene-2-carboxylate

: 1417797-96-6
5-(4'-(N-((dimethylamino)methylene)sulfamoyl)-6-methoxy-[1,1'-biphenyl]-3-yl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 25 - 85 °C

1.2: 0 °C / pH Ca_. 1

2.1: oxalyl dichloride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

With oxalyl dichloride; water; sodium hydroxide; In ethanol; dichloromethane;