(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Name:(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453852-36-2
Molecular Formula:C₂₈H₃₆ClFN₄O₃Si
Molecular Weight:559.156
Hs Code.:

Synonyms:(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of (S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of (S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 10 articles about (S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38041-19-9
4-aminotetrahydropyran

: 1453851-69-8
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one

: 1453852-36-2
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: In iso-butanol; at 120 ℃; for 4h; Sealed tube;

Reference yield:

: 1263414-46-5
1-chloro-2-fluoro-4-vinylbenzene

: 1453852-36-2
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: AD-mix-β / water; tert-butyl alcohol / 0 - 20 °C

2.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

4.2: 30 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

6.1: iso-butanol / 4 h / 120 °C / Sealed tube

With 1H-imidazole; AD-mix-β; potassium hexamethylsilazane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; iso-butanol; tert-butyl alcohol;

Reference yield:

: 1453854-84-6
(R)-1-(4-chloro-3-fluorophenyl)ethane-1,2-diol

: 1453852-36-2
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

3.2: 30 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

5.1: iso-butanol / 4 h / 120 °C / Sealed tube

With 1H-imidazole; potassium hexamethylsilazane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; iso-butanol;