methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate
CAS No.:1275467-08-7
Molecular Formula:C₃₁H₃₁NO₅
Molecular Weight:497.591
Hs Code.:

Synonyms:methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate

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Technology Process of methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate

There total 4 articles about methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1275466-78-8
(E)-methyl 1-acetyl-5-(3-ethoxy-3-oxoprop-1-enyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate

: 1275467-08-7
methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In ethanol; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1002/anie.201006381

Reference yield:

: 31930-36-6,31930-37-7
ethyl (E)-3-iodopropenoate

: 1275467-08-7
methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

2: tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; oxygen; copper(II) acetate monohydrate / cyclohexanone / 18 h / 20 °C

3: palladium 10% on activated carbon; ammonium formate / ethanol / 16 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; palladium 10% on activated carbon; oxygen; ammonium formate; copper(II) acetate monohydrate; triethylamine; In ethanol; cyclohexanone; N,N-dimethyl-formamide;
DOI:10.1002/anie.201006381

Reference yield:

: 1275466-22-2
(E)-ethyl 6-(trityloxy)hex-2-en-4-ynoate

: 1275467-08-7
methyl 5-(3-ethoxy-3-oxopropyl)-4-(trityloxymethyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; oxygen; copper(II) acetate monohydrate / cyclohexanone / 18 h / 20 °C

2: palladium 10% on activated carbon; ammonium formate / ethanol / 16 h / 80 °C / Inert atmosphere

With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; palladium 10% on activated carbon; oxygen; ammonium formate; copper(II) acetate monohydrate; In ethanol; cyclohexanone;
DOI:10.1002/anie.201006381