1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Base Information

Chemical Name:1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
CAS No.:1239617-28-7
Molecular Formula:C₂₅H₁₉FN₂
Molecular Weight:366.438
Hs Code.:

Synonyms:1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

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Chemical Property of 1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

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Technology Process of 1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

There total 2 articles about 1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 61-54-1
tryptamine

: 1042369-43-6
2-[2-(4-fluorophenyl)ethynyl]benzaldehyde

: 1239617-28-7
1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Guidance literature:: With 1-butyl-3-methylimidazolium chloride; ytterbium(III) triflate; In dichloromethane; at 120 ℃; for 1h; under 10.5011 Torr; Catalytic behavior; Inert atmosphere; Microwave irradiation;
DOI:10.1039/c5cc01555c

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 303744-04-9
1-(2-iodo-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline

: 1239617-28-7
1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Guidance literature:: 1-(2-iodo-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline; With di-tert-butyl dicarbonate; sodium hydroxide; In 1,4-dioxane; water; at 80 ℃;

1-ethynyl-4-fluorobenzene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 80 ℃; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo1006174

Reference yield: 71.0%

: 1239617-28-7
1-(2-((4-fluorophenyl)ethynyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

: 1239617-64-1
C₂₅H₁₈FN₂⁽¹⁺⁾*F₆Sb^(1-)

Guidance literature:: With silver hexafluoroantimonate; triphenylphosphine gold (I) chloride; In toluene; at 110 ℃; for 12h; sealed tube;
DOI:10.1021/jo1006174