5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione

Base Information

Chemical Name:5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione
CAS No.:117280-09-8
Molecular Formula:C₂₅H₂₅ClN₂S₂
Molecular Weight:453.072
Hs Code.:

Synonyms:5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione

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Chemical Property of 5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione

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Technology Process of 5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione

There total 11 articles about 5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 117280-08-7
5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl-]1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one

: 117280-09-8
5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione

Guidance literature:: With tetraphosphorus decasulfide; In chloroform; for 4h; Heating;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 19172-47-5,94367-93-8
Lawessons reagent

: 117280-08-7
5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl-]1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one

: 117280-09-8
5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione

Guidance literature:: In toluene;

Reference yield:

: 538-93-2
1-phenyl-2-methylpropane

: 117280-09-8
5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / AlCl₃ / 1,2-dichloro-ethane / 4 h

2: 89 percent / hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 20 - 160 °C

3: NaBH₄, BF₃*OEt₂

4: 97 percent / CrO₃, celite, pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 70 percent / triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

6: 93 percent / CHCl₃ / 2 h / Heating

7: sodium iodide / tetrahydrofuran / 2 h / Heating

8: liquid ammonia / tetrahydrofuran / 4 h / -30 - 20 °C

9: acetic acid / propan-2-ol / 20 h / Heating

10: 94 percent / P₂S₅ / CHCl₃ / 4 h / Heating

With pyridine; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; tetraphosphorus decasulfide; Celite; boron trifluoride diethyl etherate; ammonia; sulfur; hydrazine hydrate; acetic acid; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; chloroform; ethylene glycol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/0223-5234(96)85877-6