4-(4-isobutylphenyl)-4-oxobutanoic acid

Base Information

• Chemical Name: 4-(4-isobutylphenyl)-4-oxobutanoic acid
• CAS No.: 73120-67-9
• Molecular Formula: C14H18O3
• Molecular Weight: 234.295
• Mol file: 73120-67-9.mol

Synonyms:4-oxo-4-(2'-methylpropyl)phenylbutanoic acid;4-(4-isobutylphenyl)-4-oxobutanoic acid;3-(4-isobutylbenzoyl)propionic acid;

Chemical Property of 4-(4-isobutylphenyl)-4-oxobutanoic acid

Chemical Property:

• Vapor Pressure: 1.58E-07mmHg at 25°C
• Boiling Point: 412°C at 760 mmHg
• Flash Point: 217.1°C
• PSA: 54.37000
• Density: 1.09g/cm³
• LogP: 2.93260

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(4-ISOBUTYLPHENYL)-4-OXOBUTANOICACID ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-isobutylphenyl)-4-oxobutanoic acid

There total 1 articles about 4-(4-isobutylphenyl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

succinic acid anhydride (108-30-5) + 1-phenyl-2-methylpropane (538-93-2) → 4-(4-isobutylphenyl)-4-oxobutanoic acid (73120-67-9)

Guidance literature:

succinic acid anhydride; 1-phenyl-2-methylpropane; With aluminum (III) chloride; In 1,1-dichloroethane; at 20 ℃; for 1h; Heating / reflux;

With hydrogenchloride; In 1,1-dichloroethane; water; at 20 ℃; for 0.166667h;

Reference yield: 89.0%

4-(4-isobutylphenyl)-4-oxobutanoic acid (73120-67-9) → 4-(4'-s-butylphenyl)butanoic acid (1041514-31-1)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In ethylene glycol; at 20 - 160 ℃;

DOI:10.1016/0223-5234(96)85877-6

Reference yield: 89.0%

4-(4-isobutylphenyl)-4-oxobutanoic acid (73120-67-9) + trimethyl orthoformate (149-73-5) → dimethyl 2-(4-isobutylphenyl)succinate (97728-48-8)

Guidance literature:

With perchloric acid; thallium(III) nitrate; for 5h; Ambient temperature;

upstream raw materials:

succinic acid anhydride

1-phenyl-2-methylpropane

Downstream raw materials:

5-(4-isobutylphenyl)furan-2(3H)-one

dimethyl 2-(4-isobutylphenyl)succinate

4-(4'-s-butylphenyl)butanoic acid

4-(4-Isobutyl-phenyl)-butan-1-ol

Refernces

• 1、 Khisal, Subuhi,Mishra, Ravinesh,Partap, Sangh,Siddiqui, Aness Ahmad,Yar, Mohammad Shahar. "Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues". . . Retrieved 2020/04/07.
• 2、 Khokra, Sukhbir Lal,Khan, Shah Alam,Thakur, Pramila,Chowdhary, Deepika,Ahmad, Aftab,Husain, Asif. "Synthesis, Molecular Docking and Potential Antioxidant Activity of Di/Trisubstituted Pyridazinone Derivatives". . p. 739 - 750. Retrieved 2016/10/04.