1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol

Base Information

Chemical Name:1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol
CAS No.:123167-29-3
Molecular Formula:C₃₀H₃₈O₃Si
Molecular Weight:474.715
Hs Code.:

Synonyms:1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol

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Chemical Property of 1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol

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Technology Process of 1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol

There total 4 articles about 1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 123167-29-3
1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / pyridiniump-toluenesulfonate (PPTS) / CH₂Cl₂ / 3 h / 25 °C

2: 1.) a) EtMgBr, b) CuI / 1.) a) THF, 65 deg C, 1 h, b) 0 deg C, 30 min, 2.) 0 deg C, 30 min

With copper(l) iodide; ethylmagnesium bromide; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1021/jo00284a025

Reference yield:

: 88158-68-3
4-(tert-butyldiphenylsilyloxy)-1-butyne

: 123167-29-3
1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) from -78 deg C to 25 deg C, 12 h

2: 96 percent / KOH / diethyl ether / 1 h / -20 - 0 °C

3: 1.) a) EtMgBr, b) CuI / 1.) a) THF, 65 deg C, 1 h, b) 0 deg C, 30 min, 2.) 0 deg C, 30 min

With potassium hydroxide; copper(l) iodide; n-butyllithium; ethylmagnesium bromide; In diethyl ether;
DOI:10.1021/jo00284a025

Reference yield:

: 88159-03-9
5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-yn-1-ol

: 123167-29-3
1-(tert-butyldiphenylsiloxy)-9-<(tetrahydropyran-2'-yl)-oxy>nona-3,6-diyne-1,9-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / KOH / diethyl ether / 1 h / -20 - 0 °C

2: 1.) a) EtMgBr, b) CuI / 1.) a) THF, 65 deg C, 1 h, b) 0 deg C, 30 min, 2.) 0 deg C, 30 min

With potassium hydroxide; copper(l) iodide; ethylmagnesium bromide; In diethyl ether;
DOI:10.1021/jo00284a025